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Clomid for Men – Does it Really Boost Testosterone?

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Clomid® for men (Clomiphene Citrate) is an off-label medication that boosts sperm production and testosterone levels. The main advantage it has over testosterone replacement therapy (TRT) for younger men wishing to optimize their hormones is that it doesn't harm fertility.


Clomid® Summary:

• Clomiphene citrate (Clomid®) is a selective estrogen receptor modulator, primarily a medication used to treat infertility in women.
• Clomid is often used 'off label' 1 to treat infertility in men.
• Clomid is also used 'off label' as a testosterone booster2 while maintaining fertility in men.
• Clomid blocks estrogen receptors in the brain, increasing the secretion of gonadotropin-releasing hormones (GnRH) called follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
• FSH and LH are released into the circulation, acting on the testes and ovaries to kick start and support their reproductive functions.
• In women, gonadotropins stimulate follicle maturation in the ovaries, encouraging ovulation and increasing estradiol in the blood.
• In men, Clomid stimulates testosterone production by blocking estrogen receptors in the brain. It essentially tricks the brain into thinking it needs more hormones, producing more FHS and LH, which are responsible for testosterone and sperm production.

What Is Clomid Used for In Men?

Clomiphene and its derivative enclomiphene increase testosterone levels in men who want to maintain fertility. At Male Excel, we only prescribe bioidentical hormone replacement therapy to men over 38 to protect the fertility of younger men. However, Clomid is very effective for men under the age of 38 who suffer from reduced testosterone levels and are experiencing the associated side effects.

Why men under 38 might need to take Clomid?

  • Lack of Energy
  • Depression
  • Loss of vitality
  • Weight gain
  • Muscle loss (Atrophy)
  • Weight Gain
  • To increase Testosterone level
  • To increase sperm count

Bioidentical testosterone replacement therapy slows and even stops the natural production of testosterone in the testicles. For this reason, Clomid is an excellent option for men wishing to continue natural production and maintain fertility.

Compared with bioidentical testosterone replacement therapy, Clomid is a great alternative because:

  • Clomid maintains and stimulates natural testosterone production
  • Clomid has few side effects and has a long track record
  • Clomid comes in tablet form.
  • It is cheap and affordable.

25-50mg of Clomid per day usually increases sperm count and testosterone levels (free and total) within a couple of months. Clomid increases LH, which stimulates the body to produce more testosterone, while FSH works by supporting the sperm until they mature during spermatogenesis, which takes around 74 days. Since testosterone is the primary hormone required for the synthesis of sperm, its higher concentration in the body translates to the production of more sperm.

Studies [2] show that low does Clomid administration increases testosterone levels, quoting
"Low dose clomiphene citrate effectively elevates serum testosterone levels and improves the testosterone/estradiol ratio in men with hypogonadism. This therapy represents an alternative to testosterone therapy by stimulating the endogenous androgen production pathway." Shabsigh A, Kang Y, Shabsign R, et al.

Does Clomid Work as Well as TRT?

Clomid uses a different approach to increasing testosterone than traditional TRT (testosterone replacement therapy). It is not quite as effective as TRT at optimizing testosterone. However, you can expect to achieve between a 100 and 200 % increase in testosterone levels using Clomid. This increase is usually more than enough for most men to experience significant relief from the symptoms of low testosterone levels while maintaining fertility.

The benefits of Clomid are the same as with TRT

  • Improved libido and sexual satisfaction
  • Reduced bad cholesterol (LDL)
  • Increased metabolism
  • Improved cardiovascular health
  • Increased lean muscle mass and strength
  • Decreased body fat (dangerous visceral fat)
  • Increased confidence, positivity, memory, and brain function
  • Reduced feelings of depression
  • Increased energy levels
  • Improved sleep
  • More equipped to deal with stress
  • Reduced risk of type 2 diabetes and relief from insulin resistance

What are The Benefits of Clomid over Injections and Creams?

Clomid promotes the natural production of testosterone in the testicles. Clomid is an easy-to-swallow pill taken daily, and it is available in generic form, making it cheap to buy. Clomid does not shrink your testicles like traditional TRT and preserves fertility. 4 Results vary depending on your base hormone levels, with few side effects. With Clomid, there is no need to inject, and you don't have the same transference risks you have with testosterone cream.

What Are the Downsides to Clomid?

If you have reduced testosterone levels with Clomid, it takes longer to see results than with testosterone injection therapy and creams. Clomid can reduce libido in some patients; however, this is unusual. There have been a few reports of blurred vision in those taking Clomid; again, this is pretty rare.

What are the Side Effects of Clomid in Men?

The most common side effects in men taking Clomid may include: 5

  • Changes in Mood
  • Sore Breasts
  • Blurry vision
  • Weight gain
  • Acne

Some men rarely experience other reactions like high blood pressure (hypertension), altered taste, asthma, flushing, nausea,  extreme thirst, and aching joints.

Is Clomid Right for a Good Choice for Low T?

Most men tolerate Clomid very well. In studies,6 most patients who take it see improvement from reduced testosterone symptoms within 3 years of starting treatment.

If you are under 38 and experiencing low testosterone levels' side effects, we would advise taking our 'at home blood spot test.' This easy-to-use test kit eliminates needing to visit a clinic and draw blood. Once sent to our labs, the test will highlight your key hormone levels and establish if Clomid would help increase your testosterone to reduce the associated symptoms.

Disclaimer: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please consult a doctor.

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[1] DiGiorgio L, Sadeghi-Nejad H. Off label therapies for testosterone replacement. Transl Androl Urol. 2016;5(6):844-849. doi:10.21037/tau.2016.08.15

[2] Shabsigh A, Kang Y, Shabsign R, et al. Clomiphene citrate effects on testosterone/estrogen ratio in male hypogonadism. J Sex Med 2005;2:716-21. 10.1111/j.1743-6109.2005.00075.x 

[3] Kaminetsky J, Werner M, Fontenot G, Wiehle RD. Oral enclomiphene citrate stimulates the endogenous production of testosterone and sperm counts in men with low testosterone: comparison with testosterone gel. J Sex Med. 2013 Jun;10(6):1628-35. doi: 10.1111/jsm.12116. Epub 2013 Mar 26. PMID: 23530575.
https://pubmed.ncbi.nlm.nih.gov/23530575/

[4] Kim ED, McCullough A, Kaminetsky J. Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement. BJU Int. 2016 Apr;117(4):677-85. doi: 10.1111/bju.13337. Epub 2015 Oct 23. PMID: 26496621.

[5 ]Krzastek SC, Sharma D, Abdullah N, Sultan M, Machen GL, Wenzel JL, Ells A, Chen X, Kavoussi M, Costabile RA, Smith RP, Kavoussi PK. Long-Term Safety and Efficacy of Clomiphene Citrate for the Treatment of Hypogonadism. J Urol. 2019 Nov;202(5):1029-1035. doi: 10.1097/JU.0000000000000396. Epub 2019 Oct 9. PMID: 31216250.

[6] Mbi Feh MK, Wadhwa R. Clomiphene. [Updated 2022 Jan 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559292/